CAI is very pleased to introduce ClariCELL™ kinase cell-based compound testing services and assay-ready kits for the complete TEC family of tyrosine kinase targets!
Available targets in the TEC family:
|BTK [C481S] (data)|
|BTK [T474A] (data)|
|BTK [T474M] (data)|
|ITK - mouse (data)|
TEC family cytoplasmic tyrosine kinases are important modulators in signaling pathways related to inflammation and immune responses. BTK, the most well studied TEC family kinase to date, is a key regulator of B-cell development and signaling. ITK, on the other hand, plays an essential role in T-cell signaling. Numerous drug discovery programs exist to develop and characterize TEC family inhibitors in oncology, inflammation, and immunology indications. Since these targets are instrumental in signaling pathways related to human disease, cell-based drug discovery assays for assessing small molecule activity against TEC family kinases are invaluable tools for potency and selectivity determinations in the development of therapeutic molecules.
Please contact us for further information or for ordering compound testing services or assay kits!